On the role of miRNAs in adult tissues

We are thrilled to share a pre-print describing a novel approach to interfere with global microRNA activity in cells and in living animals without affecting miRNA biogenesis or miRNA abundance. Inducible and reversible inhibition of miRNA-mediated gene repression in vivobiorxiv.org/content/10.1101/2021.06.01.445680v1 The approach is based on a peptide (T6B) previously generated by Gunter Meister and TomContinue reading “On the role of miRNAs in adult tissues”

Congratulations Dr. Xiaoyi Li!!!

A big congratulations to our own Xiaoyi Li who today brilliantly earned her PhD with a wonderful presentation to cap five years of hard work and a remarkable first author paper in Molecular Cell. Xiaoyi will soon move to the west coast to start her postdoctoral training. Running a lab can be frustrating at times,Continue reading “Congratulations Dr. Xiaoyi Li!!!”

We are hiring!

We have an NIH-funded postdoctoral position available immediately to study BRAF-driven pediatric brain cancers. You will use ex vivo and in vivo somatic chromosomal engineering to model and characterize pediatric brain tumors driven by the BRAF oncogene, with a particular focus on tumors driven by BRAF gene fusions. The goals include defining the molecular mechanismsContinue reading “We are hiring!”

Retreat 2018: celebrating the first 10 years

This year we headed upstate for a two days of sport, science, brainstorming, and good food. Gaspare entertained everybody with his unsuspected skills as piano player and singer. The brainstorming session produced many interesting new ideas, with Nathan, Ram, and Jinny securing the top three places (and an Amazon gift card each!).   It wasContinue reading “Retreat 2018: celebrating the first 10 years”

Ping Mu: from student to PI

Ping Mu, our very first graduate student, after completing  a very successful postdoc with Charles Sawyers, has now started his own lab at UTSW where he will continue his ground breaking work on prostate cancer. If you are looking for a postdoctoral position I cannot think of a better environment and a better lab! ToContinue reading “Ping Mu: from student to PI”

Modeling brain cancer with CRISPR

We are proud to announce that our latest manuscript: “Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target”, has been just published in Nature Communications. This work was the result of a truly collaborative effort  between our lab and the lab ot our neighbors at MSKCC: Robert Benezra and Maurizio Scaltriti.Continue reading “Modeling brain cancer with CRISPR”

A goodbye and a welcome

Last Friday was Stephanie Cervino’s last day in our lab. Our fearless admin assistant/lab manager/organizer is going back to school. Needless to say, Stephanie will be missed by us all, but we are comforted by the hope that she will not forget us, and by the certainty that she will do great things! Good luck,Continue reading “A goodbye and a welcome”