Publications

Selected publications in chronological order (most recent first)

A full list can be found at our google scholar page.

Cook, PJ., Rozario, T. Kannan, R., de Leon, ES., Drilon, A., Rosenblum, M.K.,  Scaltriti, M., Benezra, R., and Ventura, A. (2017).
Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.
Nature communications 6.

Perez, A., Pritykin, Y., Vidigal, J., Chhangawala, S., Zamparo, L., Leslie, C., and Ventura, A. (2017).
GuideScan software for improved single and paired CRISPR guide RNA design.
Nature Biotechnology, 347-349.

Ventura, A. (2016).
NORAD: Defender of the Genome.
Trends in Genetics 32, 390-392.

Maddalo, D., and Ventura, A. (2016).
Somatic Engineering of Oncogenic Chromosomal Rearrangements: A Perspective.
Cancer Research 76, 4918-4923.

Li, X., Wu, R., and Ventura, A. (2016).
The present and future of genome editing in cancer research.

Human Genetics 135, 1083-1092.

Andolina, D., Di Segni, M., Bisicchia, E., D’Alessandro, F., Cestari, V., Ventura, A., Concepcion, C., Puglisi-Allegra, S., and Ventura, R. (2016).
Effects of lack of microRNA-34 on the neural circuitry underlying the stress response and anxiety.
Neuropharmacology 107, 305-316.

Vidigal, J.A., and Ventura, A. (2015a).
Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries.
Nature communications 6.

Vidigal, J.A., and Ventura, A. (2015b).
The biological functions of miRNAs: lessons from in vivo studies.
Trends in cell biology 25, 137-147.

Tricarico, R., Cortellino, S., Riccio, A., Jagmohan-Changur, S., Van der Klift, H., Wijnen, J., Turner, D., Ventura, A., Rovella, V., and Percesepe, A. (2015).
Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis.
Oncotarget 6, 42892.

La Rocca, G., Olejniczak, S.H., González, A.J., Briskin, D., Vidigal, J.A., Spraggon, L., DeMatteo, R.G., Radler, M.R., Lindsten, T., and Ventura, A. (2015).
In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.

Proceedings of the National Academy of Sciences 112, 767-772.

Kannan, R., and Ventura, A. (2015).
The CRISPR revolution and its impact on cancer research.

Swiss Med Weekly 145, 14230w.

Han, Y.-C., Vidigal, J.A., Mu, P., Yao, E., Singh, I., González, A.J., Concepcion, C.P., Bonetti, C., Ogrodowski, P., and Carver, B. (2015).
An allelic series of miR-17 [sim] 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron.
Nature genetics 47, 766-775.

Fiori, E., Babicola, L., Andolina, D., Coassin, A., Pascucci, T., Patella, L., Han, Y.-C., Ventura, A., and Ventura, R. (2015).
Neurobehavioral alterations in a genetic murine model of Feingold Syndrome 2
.
Behavior genetics 45, 547-559.

Zindy, F., Kawauchi, D., Lee, Y., Ayrault, O., Merzoug, L.B., McKinnon, P.J., Ventura, A., and Roussel, M.F. (2014).
Role of the miR-17∼ 92 cluster family in cerebellar and medulloblastoma development.

Biology open 3, 597-605.

Maddalo, D., Manchado, E., Concepcion, C.P., Bonetti, C., Vidigal, J.A., Han, Y.-C., Ogrodowski, P., Crippa, A., Rekhtman, N., and de Stanchina, E. (2014).
In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
.
Nature 516, 423-427.

Han, Y.-C., and Ventura, A. (2013).
Control of TFH differentiation by a microRNA cluster.
Nature immunology 14, 770-771.

Vidigal, J.A., and Ventura, A. (2012).
Embryonic stem cell miRNAs and their roles in development and disease.
Seminars in cancer biology (Academic Press).

Concepcion, C.P., Han, Y.-C., Mu, P., Bonetti, C., Yao, E., D’andrea, A., Vidigal, J.A., Maughan, W.P., Ogrodowski, P., and Ventura, A. (2012a).
Intact p53-dependent responses in miR-34–deficient mice.
PLoS Genet 8, e1002797.

Concepcion, C.P., Bonetti, C., and Ventura, A. (2012b).
The miR-17-92 family of microRNA clusters in development and disease.
Cancer journal (Sudbury, Mass) 18, 262.

Yao, E., and Ventura, A. (2011).
A new role for miR-182 in DNA repair.
Molecular cell 41, 135-137.

Yang, J.-S., Phillips, M.D., Betel, D., Mu, P., Ventura, A., Siepel, A.C., Chen, K.C., and Lai, E.C. (2011).
Widespread regulatory activity of vertebrate microRNA* species.
Rna 17, 312-326.

Sage, J., and Ventura, A. (2011).
miR than meets the eye.
Genes & development 25, 1663-1667.

Lal, A., Thomas, M.P., Altschuler, G., Navarro, F., O’Day, E., Li, X.L., Concepcion, C., Han, Y.-C., Thiery, J., and Rajani, D.K. (2011).
Capture of microRNA–bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling.
PLoS genetics 7, e1002363.

de Pontual, L., Yao, E., Callier, P., Faivre, L., Drouin, V., Cariou, S., Van Haeringen, A., Geneviève, D., Goldenberg, A., and Oufadem, M. (2011).
Germline deletion of the miR-17 [sim] 92 cluster causes skeletal and growth defects in humans.
Nature genetics 43, 1026-1030.

Agostini, M., Tucci, P., Steinert, J.R., Shalom-Feuerstein, R., Rouleau, M., Aberdam, D., Forsythe, I.D., Young, K.W., Ventura, A., and Concepcion, C.P. (2011).
microRNA-34a regulates neurite outgrowth, spinal morphology, and function.
Proceedings of the National Academy of Sciences 108, 21099-21104.

Ventura, A., and Jacks, T. (2009).
MicroRNAs and cancer: short RNAs go a long way.
Cell 136, 586-591.

Mu, P., Han, Y.-C., Betel, D., Yao, E., Squatrito, M., Ogrodowski, P., de Stanchina, E., D’Andrea, A., Sander, C., and Ventura, A. (2009).
Genetic dissection of the miR-17∼ 92 cluster of microRNAs in Myc-induced B-cell lymphomas.
Genes & development 23, 2806-2811.

Ventura, A., Young, A.G., Winslow, M.M., Lintault, L., Meissner, A., Erkeland, S.J., Newman, J., Bronson, R.T., Crowley, D., and Stone, J.R. (2008).
Targeted deletion reveals essential and overlapping functions of the miR-17∼ 92 family of miRNA clusters.
Cell 132, 875-886.

Ventura, A., Kirsch, D.G., McLaughlin, M.E., Tuveson, D.A., Grimm, J., Lintault, L., Newman, J., Reczek, E.E., Weissleder, R., and Jacks, T. (2007).
Restoration of p53 function leads to tumour regression in vivo.
Nature 445, 661-665.

Ventura, A., Meissner, A., Dillon, C.P., McManus, M., Sharp, P.A., Van Parijs, L., Jaenisch, R., and Jacks, T. (2004).
Cre-lox-regulated conditional RNA interference from transgenes.
Proceedings of the National Academy of Sciences of the United States of America 101, 10380-10385.